Molecular Evolution of MERS Coronavirus: Dromedaries as a Recent Intermediate Host or Long-Time Animal Reservoir?
Identifieur interne : 000C72 ( Main/Exploration ); précédent : 000C71; suivant : 000C73Molecular Evolution of MERS Coronavirus: Dromedaries as a Recent Intermediate Host or Long-Time Animal Reservoir?
Auteurs : Susanna K. P. Lau [Hong Kong] ; Antonio C. P. Wong ; Terrence C. K. Lau ; Patrick C. Y. Woo [Hong Kong]Source :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Arabie saoudite, Biologie informatique (), Cadres ouverts de lecture, Chameaux (virologie), Conformation des protéines, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Glycoprotéine de spicule des coronavirus (), Glycoprotéine de spicule des coronavirus (génétique), Génome viral, Humains, Infections à coronavirus (virologie), Modèles biologiques, Phylogénie, Phylogéographie, Recombinaison génétique, Relation structure-activité, Réservoirs d'agents pathogènes, Sélection génétique, Séquence d'acides aminés, Zoonoses (virologie), Évolution moléculaire.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus.
- virologie : Chameaux, Infections à coronavirus, Zoonoses.
- Animaux, Arabie saoudite, Biologie informatique, Cadres ouverts de lecture, Conformation des protéines, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Génome viral, Humains, Modèles biologiques, Phylogénie, Phylogéographie, Recombinaison génétique, Relation structure-activité, Réservoirs d'agents pathogènes, Sélection génétique, Séquence d'acides aminés, Évolution moléculaire.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Camelus (virology), Computational Biology (methods), Coronavirus Infections (virology), Disease Reservoirs, Evolution, Molecular, Genome, Viral, Humans, Middle East Respiratory Syndrome Coronavirus (classification), Middle East Respiratory Syndrome Coronavirus (genetics), Models, Biological, Open Reading Frames, Phylogeny, Phylogeography, Protein Conformation, Recombination, Genetic, Saudi Arabia, Selection, Genetic, Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (genetics), Structure-Activity Relationship, Whole Genome Sequencing, Zoonoses (virology).
- MESH :
- chemical , chemistry : Spike Glycoprotein, Coronavirus.
- classification : Middle East Respiratory Syndrome Coronavirus.
- genetics : Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus.
- methods : Computational Biology.
- virology : Camelus, Coronavirus Infections, Zoonoses.
- Amino Acid Sequence, Animals, Disease Reservoirs, Evolution, Molecular, Genome, Viral, Humans, Models, Biological, Open Reading Frames, Phylogeny, Phylogeography, Protein Conformation, Recombination, Genetic, Saudi Arabia, Selection, Genetic, Structure-Activity Relationship, Whole Genome Sequencing.
Abstract
While dromedary camels are the immediate animal source of MERS coronavirus (MERS-CoV) infection, the evolutionary origin of MERS-CoV remains obscure. We analyzed 219 camel and human MERS-CoV genome sequences available in GenBank. Phylogenetic analysis showed that 5 and 214 strains belong to clade A and B, respectively, with clade A further divided into lineage A1 (3 human strains) and lineage A2 (2 camel strains), and clade B divided into B1 to B6 (each containing both human and camel strains). Recombination analysis showed potential recombination events in five strains from dromedaries in Saudi Arabia, with recombination between lineage B5 and B3 in four strains, and between lineage B3 and B4 in one strain. The spike protein showed the highest number of amino acid substitutions, especially between A2 and other lineages, and contained positively selected codons. Notably, codon 1020 was positively selected among B and B5 strains, and can distinguish between clade A (Q1020) and B (R1020/H1020) strains, suggesting that this residue may play a role in the evolution of S protein during divergence of different lineages. The time of the most recent common ancestor of all MERS-CoV was dated to approximately 2010. The implications on the role of camels in the evolution of MERS-CoV are discussed.
Url:
DOI: 10.3390/ijms18102138
PubMed: 29035289
PubMed Central: 5666820
Affiliations:
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Lau</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-18-02138">State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam</wicri:regionArea><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation><affiliation><nlm:aff id="af2-ijms-18-02138">Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong;<email>antonwcp@hku.hk</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijms-18-02138">Research Centre of Infection and Immunology, the University of Hong Kong, Pokfulam, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Research Centre of Infection and Immunology, the University of Hong Kong, Pokfulam</wicri:regionArea><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ijms-18-02138">Carol Yu Centre for Infection, the University of Hong Kong, Pokfulam, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Carol Yu Centre for Infection, the University of Hong Kong, Pokfulam</wicri:regionArea><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af5-ijms-18-02138">Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, the University of Hong Kong, Pokfulam, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, the University of Hong Kong, Pokfulam</wicri:regionArea><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Antonio C P" sort="Wong, Antonio C P" uniqKey="Wong A" first="Antonio C. P." last="Wong">Antonio C. P. Wong</name><affiliation><nlm:aff id="af2-ijms-18-02138">Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong;<email>antonwcp@hku.hk</email></nlm:aff></affiliation></author><author><name sortKey="Lau, Terrence C K" sort="Lau, Terrence C K" uniqKey="Lau T" first="Terrence C. K." last="Lau">Terrence C. K. Lau</name><affiliation><nlm:aff id="af6-ijms-18-02138">Department of Biomedical Sciences, College of Science and Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong;<email>chiklau@cityu.edu.hk</email></nlm:aff></affiliation></author><author><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-18-02138">State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam</wicri:regionArea><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation><affiliation><nlm:aff id="af2-ijms-18-02138">Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong;<email>antonwcp@hku.hk</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijms-18-02138">Research Centre of Infection and Immunology, the University of Hong Kong, Pokfulam, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Research Centre of Infection and Immunology, the University of Hong Kong, Pokfulam</wicri:regionArea><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ijms-18-02138">Carol Yu Centre for Infection, the University of Hong Kong, Pokfulam, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Carol Yu Centre for Infection, the University of Hong Kong, Pokfulam</wicri:regionArea><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af5-ijms-18-02138">Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, the University of Hong Kong, Pokfulam, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, the University of Hong Kong, Pokfulam</wicri:regionArea><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno 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xml:lang="en"><term>Camelus</term><term>Coronavirus Infections</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Disease Reservoirs</term><term>Evolution, Molecular</term><term>Genome, Viral</term><term>Humans</term><term>Models, Biological</term><term>Open Reading Frames</term><term>Phylogeny</term><term>Phylogeography</term><term>Protein Conformation</term><term>Recombination, Genetic</term><term>Saudi Arabia</term><term>Selection, Genetic</term><term>Structure-Activity Relationship</term><term>Whole Genome Sequencing</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Arabie saoudite</term><term>Biologie informatique</term><term>Cadres ouverts de lecture</term><term>Conformation des protéines</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Génome viral</term><term>Humains</term><term>Modèles biologiques</term><term>Phylogénie</term><term>Phylogéographie</term><term>Recombinaison génétique</term><term>Relation structure-activité</term><term>Réservoirs d'agents pathogènes</term><term>Sélection génétique</term><term>Séquence d'acides aminés</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>While dromedary camels are the immediate animal source of MERS coronavirus (MERS-CoV) infection, the evolutionary origin of MERS-CoV remains obscure. We analyzed 219 camel and human MERS-CoV genome sequences available in GenBank. Phylogenetic analysis showed that 5 and 214 strains belong to clade A and B, respectively, with clade A further divided into lineage A1 (3 human strains) and lineage A2 (2 camel strains), and clade B divided into B1 to B6 (each containing both human and camel strains). Recombination analysis showed potential recombination events in five strains from dromedaries in Saudi Arabia, with recombination between lineage B5 and B3 in four strains, and between lineage B3 and B4 in one strain. The spike protein showed the highest number of amino acid substitutions, especially between A2 and other lineages, and contained positively selected codons. Notably, codon 1020 was positively selected among B and B5 strains, and can distinguish between clade A (Q1020) and B (R1020/H1020) strains, suggesting that this residue may play a role in the evolution of S protein during divergence of different lineages. The time of the most recent common ancestor of all MERS-CoV was dated to approximately 2010. The implications on the role of camels in the evolution of MERS-CoV are discussed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="To, K K" uniqKey="To K">K.K. To</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. 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Wong</name></noCountry><country name="Hong Kong"><noRegion><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name></noRegion><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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